CJC-1295

What is CJC-1295?

Native GHRH is broken down within minutes by the enzyme DPP-IV. CJC-1295 is a modified 29-residue GHRH analog with four substitutions that protect it from that cleavage. The compound appears in the literature in two variants: the original, which carries a drug-affinity-complex (DAC) group that binds serum albumin, and the version without it, sometimes called 'Mod GRF 1-29'. The COA for your lot states which form was tested.

What is CJC-1295 studied for in research?

• GH and IGF-1 secretion. Two 2006 clinical-pharmacology papers in *J Clin Endocrinol Metab* characterised prolonged stimulation of GH and IGF-1 [1] and, notably, that GH secretion remained pulsatile during continuous stimulation [2] — the two most-cited references for the compound.
• GHRH-analog comparisons. It is frequently studied alongside tesamorelin, another stabilised GHRH analog; see GHRH analogs explained.

Laboratory and clinical-pharmacology findings only — APX Labs makes no claim of effect.

Specifications, purity and documentation

Identity by mass spectrometry, purity by HPLC, batch-specific COA in every order. How to read the COA →

CJC-1295 — frequently asked

Further reading

• How to Read a Peptide Certificate of Analysis (COA) — Every APX Labs order ships with a batch-specific COA. This is how to read it — and how to tell a real one from a decorative one.
• How to Reconstitute Lyophilized Peptides for Laboratory Use — Lyophilized peptides arrive as a dry cake in a sealed vial. Turning that into a solution of known concentration is simple, but the details protect the material.
• What HPLC/MS Purity Testing Actually Measures — Two techniques, two questions. HPLC asks how much; mass spectrometry asks what. A COA that answers only one is half a COA.
• GHRH Analogs Explained: CJC-1295 vs Tesamorelin — Native growth-hormone-releasing hormone lasts minutes. Two very different engineering answers to that problem are in the APX Labs catalog.